Dietary Vitamin K Intake Is Associated with Cognition and Behaviour among Geriatric Patients: The CLIP Study. Nutrients. 2. 01. Aug; 7(8): 6. 73. Justine Chouet,1. Guylaine Ferland,2. Catherine Féart,3,4. Yves Rolland,5. Nancy Presse,2. Kariane Boucher,2. Pascale Barberger- Gateau,3,4. Olivier Beauchet,1 and Cedric Annweiler. Department of Neuroscience, Division of Geriatric Medicine, Angers University Hospital; Angers University Memory Clinic; UPRES EA 4. University of Angers, UNAM, Angers F- 4. France; E- Mails: moc. J. C.); rf. sregna- uhc@tehcuae. Bl. O (O. B.)4. INSERM, ISPED, INSERM U8. Epidemiologie- Biostatistique, Bordeaux F- 3. France. 5Department of Geriatric Medicine, Institut du Vieillissement, University Hospital; INSERM U1. Toulouse F- 3. 14. France; E- Mail: rf. Robarts Research Institute, Department of Medical Biophysics, Schulich School of Medicine and Dentistry, the University of Western Ontario, London, ON N6. A 5. B7, Canada*Author to whom correspondence should be addressed; E- Mail: rf. Ae. C; Tel.: +3. 3- 2. Fax: +3. 3- 2. 41. Received 2. 01. 5 Jun 1. ![]() دانلود رایگان نرم افزار دانلود رایگان نرم افزار Simulia Abaqus 2016 دانلود رایگان نرم افزار CSI ETABS 2016. Methods. An open prospective interventional study using quantitative and qualitative instruments was performed, covering all four levels of the Kirkpatrick model. Pc6官方下载为您提供spss,SPSS的全称StatisticalProgramforSocialSciences,即社会科学统计程序。该软件是公认的最优秀的统计分析软件. · Aim. To measure final-year nursing students’ preparation for high-acuity placement with emphasis on clinical skill performance confidence. Accepted 2. 01. 5 Jul 2. Abstract. Our objective was to determine whether dietary vitamin K intake was associated with cognition and behavior among older adults. CLIP (Cognition and LIPophilic vitamins) study, were separated into two groups according to the tertiles of dietary phylloquinone intake (i. Daily dietary phylloquinone intake was estimated from 5. Cognition was assessed with Mini- Mental State Examination (MMSE); behaviour with Frontotemporal Behavioral Rating Scale (FBRS). Age, gender, social problems, education, body mass index (BMI), comorbidities, history of stroke, use vitamin K antagonists, inadequate fatty fish intake, serum thyroid- stimulating hormone (TSH), vitamin B1. Compared to participants in the lowest third of dietary phylloquinone intake (n = 6. MMSE score (2. 2. FBRS score (1. 5 ± 1. In multivariate linear regressions, log dietary phylloquinone intake was positively associated with MMSE score (adjusted β = 1. FBRS score (adjusted β = −0. Specifically, log dietary phylloquinone intake correlated negatively with FBRS subscore of physical neglect (r = −0. Higher dietary phylloquinone intake was associated with better cognition and behavior among older adults. Keywords: cognition, behavior, diet, older adults, vitamin K1. Introduction. Vitamin K is a fat- soluble substance found mainly in green vegetables and some vegetable oils. Vitamin K is classically known for its role as a coenzyme in the biological activation of seven proteins involved in blood coagulation [1]. Recently, a role for vitamin K has been demonstrated in target organs, such as the central nervous system (CNS) [2,3,4,5,6,7,8,9,1. At the neuronal level, vitamin K is involved in the synthesis of sphingolipids—a major constituent of the myelin sheath and neuronal membranes—and the biological activation of vitamin K- dependent proteins (VKDPs) involved in neuronal physiology and survival [2,3]. Insufficient levels of vitamin K may, instead, cause neuropathological dysfunction [4]. Accordingly, an epidemiological study has reported a significant association between higher serum phylloquinone concentration (i. K1) and better verbal episodic memory performance in older adults [5]. Similarly, we found that the use of vitamin K antagonists (VKAs), which deplete the active form of vitamin K, was associated with cognitive impairment [6] and a lower volume of gray matter in the hippocampus [7] among geriatric patients. Taken together, these results suggest the importance of adequate (i. K levels for optimal cognition in older adults [1. To date, no randomized controlled trial has explored the benefits of vitamin K supplementation to maintain or improve cognition and related behavioral disorders in older adults. Before conducting such an expensive and time- consuming trial, it seems important and contributory to determine whether the intake of vitamin K relates to cognitive and behavioral performance in older adults. We had the opportunity to examine the association between dietary vitamin K intake and cognitive behavioral performance in a sample of geriatric patients: the CLIP (Cognition and LIPophilic vitamins) cohort. Our objective was to determine whether dietary vitamin K intake was associated with cognitive and behavioral performance among geriatric patients. Materials and Methods. Participants. We studied in- and outpatients aged 6. CLIP study. The CLIP study is an observational cross- sectional study designed to examine the relationships between neurocognition and lipophilic vitamins among all patients consecutively hospitalized or seen in consultation in the geriatric acute care unit of the University Hospital of Angers, France, from February to April 2. After giving their informed consent for research, included participants received a full medical examination consisting of structured questionnaires, a standardized clinical examination, and a blood test. The study was conducted in accordance with the ethical standards set forth in the Helsinki Declaration (1. The entire study protocol was approved by the local ethical committee (No. Explanatory Variable: Dietary Intake of Vitamin KDietary vitamin K intake was estimated from a semi- quantitative food frequency questionnaire (FFQ) [1. The 5. 0- item FFQ used here was specifically designed to determine the daily dietary phylloquinone intake during the previous 1. It comprises 5. 0 food items identified as important contributors to phylloquinone intake (e. The FFQ was interviewer- administered in 3. Estimated phylloquinone intake was calculated for each food item by multiplying the amount of phylloquinone for that food item by the selected frequency and serving size (calculated as 0. The vitamin K FFQ shows good relative agreement with five- day food records (κ = 0. In the present analysis, the participants were categorized into two groups based on the first tertile of the dietary phylloquinone intake: those in the lowest third of dietary phylloquinone intake below 2. Dependent Variables: Neuropsychiatric Measures. Cognition was assessed by one neuropsychologist blinded from participants’ vitamin K intake using the Mini- Mental State Examination (MMSE) [1. Confusion Assessment Method [1. The MMSE is a well- established measure of global cognitive performance in older adults composed of five sections (orientation, registration, attention- calculation, recall, and language). Scores range between 3. It shows good test- retest and inter- rater reliability and performs satisfactorily against more detailed measures of cognitive function [1. Behavior was assessed at the same time as the MMSE using the Frontotemporal Behavioral Rating Scale (FBRS) [1. The FBRS indicates the presence of symptoms of four domains of behavioral disturbances (i. Each domain is scored 1 if at least 1 symptom is present, and 0 if no symptoms are present. The total FBRS score ranges from 0 (normal) to 4 (worst). The FBRS is easy to perform and has demonstrated good test- retest reliability [1. Covariables. Age, gender, social problems, education level, body mass index, comorbidity burden, history of stroke, use of VKAs, regular fatty fish and eggs intakes, serum concentrations of thyroid- stimulating hormone (TSH), vitamin B1. GFR) are covariates related to diet and cognitive behavioral performance and were used as potential confounders. Evaluation of education level was based on self- report. Participants who passed at least the Elementary School Recognition Certificate were considered to have high education level. Social problems were defined by a geriatrician (yes/no) as the existence of social and/or familial isolation with consequent difficulties to stay in the usual place of life. Comorbidity burden was estimated with the Cumulative Illness Rating Scale- Geriatrics score (CIRS- G) (range 0–6. History of stroke was sought by questioning the patients, the family physicians, and the patients’ files. Stroke was defined according to the World Health Organization criteria as rapidly developed signs of focal or global disturbance of cerebral function lasting longer than 2. In case of clinical suspicion, computed tomography or magnetic resonance imaging scan was necessary to confirm the diagnosis and to distinguish among ischemic stroke and intracranial hemorrhage. The regular use of VKAs was systematically noted from the primary care physicians’ prescriptions and sought by questioning the patients and their relatives, whatever the type of VKA used (i.
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